Objective To provide scientific basis for improving the prevention and control strategies of notifiable infectious diseases by analyzing its epidemic trend in China.Methods The surveillance data of notifiable infectious diseases in China from 2015 to 2019 were collected,and the descriptive analysis method was used for epidemiological analysis.Results From 2015 to 2019,36 notifiable infectious diseases were reported in China,with a total of 38 398 804 cases,with an average annual incidence of 559.72 per 100 000,and the overall incidence was on the rise year by year(x2=1 090 638.25,P<0.01).The annual incidence of class A infectious diseases showed no trend change(x2=0.83,P>0.05);the annual incidence of class B infectious diseases showed a decreasing trend year by year(x2=33.69,P<0.01);the annual incidence of class C infectious diseases showed an increasing trend year by year(x2=1 401 639.12,P<0.01);the incidence of viral hepatitis,acquired immune deficiency syndrome,syphilis,gonorrhea and scarlet fever of class B infectious diseases all showed an increasing trend year by year(x2=1 055.33,3 849.55,11 178.53,1 734.65,2 435.74,all P<0.01).However,the incidence of pulmonary tuberculosis was decreasing year by year(x2=7 041.21,P<0.01).The incidences of influenza,other infectious diarrhea diseases,epidemic parotitis and acute hemorrhagic conjunctivitis of class C infectious diseases were increasing year by year(x2=4 763 816.32,83 100.36,39 434.89,649.21,all P<0.01),but the incidence of hand-foot-mouth disease showed a decreasing trend year by year(x2=6 770.69,P<0.01).Conclusion We should focus on the prevention and control of class B infectious diseases such as AIDS,viral hepatitis,syphilis,gonorrhea and scarlet fever,and strengthen the prevention and control of class C infectious diseases such as influenza,mumps,other infectious diarrheal diseases and acute hemorrhagic conjunctivitis.