Objective To analyze the results of strain identification and non-tuberculous Mycobacteria drug resistance surveillance among pathogenetically positive tuberculosis patients in Shijiazhuang City from 2011 to 2020,providing a scientific basis for TB control strategies.Methods The results of strain identification and drug resistance screening results of pathogenetically positive tuberculosis patients diagnosed and registered were collated and descriptively analyzed from 2011 to 2020 in Shijiazhuang City.Results Among 6 372 pathogenetically tuberculosis patients positive strain,206 were non-tuberculous Mycobacteria,accounting for 3.23％.Non-tuberculous Mycobacteria accounted for 7.51％in retreated patients and 2.52％in new treatment cases,with a statistically significant difference(x2=61.632,P＜0.001).Smear-positive patients had a non-tuberculous Mycobacteria rate of 3.19％,while smear-negative patients had a rate of 3.31％,with no statistically significant difference(x2=0.062,P=0.803).The regional distribution of 206 non-tuberculous Mycobacterium patients varied with a statistically significant difference(x2=88.285,P＜0.001),ranging from the highest at 7.74％to the lowest at 0％.The total drug resistance of non-tuberculous Mycobacteria was as follows:isoniazid(INH)resistance rate was 86.41％,streptomycin(SM)resistance rate was 73.30％,rifampicin(RFP)resistance rate was 57.28％,ethambutol(EMB)resistance rate was 48.06％,ofloxacin(OFX)resistance rate was 54.85％,and kanamycin(KM)resistance rate was 63.11％.Fifty-three cases(25.73％)exhibited resistance to all six drugs,while 27 cases(13.11％)were susceptible to all six drugs.Additionally,70 cases were fully resistant to first-line antituberculosis drugs(INH,RFP,EMB,SM),accounting for 33.98％,while 27 cases(13.11％)demonstrated total sensitivity.Conclusion We should pay great attention to the differential diagnosis between non-tuberculous mycobacterial disease and pulmonary tuberculosis with positive etiology,and make reasonable treatment plan according to the results of drug sensitivity test and clinical effect.
TuberculosisPositive for pathogenStrain identificationMycobacterium tuberculosisNon-tuberculous MycobacteriaDrug resistance rate
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