Objective To detect tuberculosis patients among middle-aged and elderly people and diabetic patients in the community at an early stage,and to explore the effectiveness of the economics of active screening among susceptible populations in areas of high tuberculosis epidemic,and to provide a scientific basis for improving the strategy of active detection of tuberculosis patients.Methods A total of 7 858 population were screened by chest X-ray radiography in 2019 through the screening of elderly people ≥65 years old,diabetes patients,and people who had tuberculosis from 2016 to 2018 in 25 administrative villages in Qiantan Town,Jiande City.A questionnaire was also used to survey the general profile of the patients and to analyze the inputs and benefit outputs.Statistical analysis was performed using SPSS 19.0,and comparison of rates was performed using the x2 test.Results A total of 7 patients of active pulmonary tuberculosis were detected in Qiantan Town via screening of key population from May to November 2019,with a detection rate of 89.08/100 000.Among them,6 patients were initial treatment cases,accounting for 85.71%,and 1 patient was retrcatmcnt case,accounting for 14.29%,with a predominance of elderly males and asymptomatic people.Through the curing of 7 pathologically positive pulmonary tuberculosis patients,a total of 52.5 healthy people were prevented from being infected,49.875 disability adjusted life years(DALY)were saved.A total of 24 234.00 Yuan in medical costs were saved,and 2 996 600.00 Yuan in socio-economic losses were recovered.The amount of money invested in tuberculosis screening per DALY loss recovered was 6 663.06 Yuan,and the benefit-cost ratio of the screening program in high risk population of tuberculosis was 9.09.Conclusion Active screening in key populations is important for the early detection and standardization of treatment for tuberculosis patients,which is a useful complement to the passive detection and had high health economic benefits.