Objective To provide a scientific basis for the prevention and control of foodborne diseases by analyzing the epidemiological characteristics of the disease.Methods In 2021,the 14 227 cases of foodbome diseases reported from the sentinel hospital surveillance in a prefecture-level city in Henan Province were collected and subjected to binary logistic regression analysis.Results The onset of foodborne illnesses was mostly concentrated from June to September;females accounted for more cases than males(44.62%),with young and middle-aged people aged 18 to<60 years(58.48%)predominating,minors(OR=1.94,95%CI:1.65-2.29)and elderly people aged ≥60 years(OR=1.34,95%CI:1.19-1.51)were more severely affected,and the underage group(OR=2.20,95%CI:1.27-3.80)were susceptible to aggregated morbidity.The exposed foods were mainly fruits and vegetables(41.08%),but meat and its products(OR=1.29,95%CI:1.11-1.50)and mixed foods,mushrooms and algae etcetera(OR=1.38,95%CI:1.18-1.61)caused more severe poisoning symptoms.Although homes(85.98%)were the main eating place,compared with homes,severe cases were more likely to occur when eating in collective canteens(OR=3.25,95%CI:2.56-4.13)and roadside stalls(OR=3.65,95%CI:2.91-4.57),and collective canteens(OR=13.92,95%CI:8.56-22.63)foodborne illness aggregation was even higher.Conclusion Minors and the elderly are the high-risk groups for foodborne diseases,and meat and its products and mixed foods are high-risk foods.Roadside stalls and collective canteens are prone to serious illnesses,and collective canteens are more prone to aggregated food poisoning.