Objective To explore the infection status and risk factors of Hepatitis B virus(HBV)infection in gravida during period of pregnancy in a hospital in Xi'an City from 2021 to 2022,and to provide a reference basis for the prevention and control strategy of HBV infection.Methods A total of 500 gravida who were examined in our hospital from 2021 to 2022 during period of pregnancy were selected as the study subjects investigated.Those co-infection with HBV were included in the study group(n=285)and those without HBV infection were included in the control group(n=215).Relevant questionnaires and HBV antibody detection were conducted for all subjects investigated.HBV infection in 500 gravida during period of pregnancy were observed.The differences of complications and adverse period of pregnancy outcomes in gravida were analyzed.Multifactorial logistic regression method was used to analyze the factors in gravida co-infection with HBV during period of pregnancy.Results Of the 500 study subjects investigated,285 cases(57.00％)were co-infected with HBV,and 75 cases(26.32％)were positive for hepatitis B surface antigen(HBsAg).The total complication rate in the study group was lower than that in the control group,and the difference was statistically significant(x2=44.906,P＜0.05).The total incidence of adverse period of pregnancy outcomes in the study group was lower than that in the control group,and the difference was statistically significant(x2=58.011,P＜0.05).Family history of viral hepatitis type B(referred to as hepatitis B),history of blood transfusion,history of paid blood donation,history of invasive diagnosis and treatment,history of dental extraction,alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were independent risk factors for co-infection with HBV during period of pregnancy,and a history of hepatitis B vaccination was an independent protective factor for co-infection with HBV during period of pregnancy.Conclusion Co-infection with HBV during period of pregnancy significantly increase the incidence rate of complications and adverse period of pregnancy outcomes.History of blood transfusion,family history of hepatitis B,history of hepatitis B vaccination,history of paid blood donation,history of invasive diagnosis and treatment,history of dental extraction,increased ALT and AST are both high-risk factors for co-infection with HBV during period of pregnancy.Clinical detection of relevant indicators should be strengthened to significantly improve the outcomes of maternal and infant during period of pregnancy.
Period of pregnancyHBVInfection statusRisk factorAdverse pregnancy outcomesAnalysis
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