Analysis of clinical features and risk factors of anticoagulant rodenticide poisoning patients
Objective To explore the clinical features of patients with anticoagulant rodenticide poisoning and analyze its related risk factors,and to provide a reference basis for early diagnosis and treatment of patients with anticoagulant rodenticide poisoning.Methods A total of 94 patients with anticoagulant rodenticide poisoning admitted to the emergency department of a hospital in the Kashgar Region from January 2018 to March 2023 were collected.The patients were divided into two groups according to whether they had bleeding manifestations.The bleeding patients were set up as group A(51 cases)and the non-bleeding patients were set up as group B(43 cases).The clinical data of the two groups were compared.Logistic regression was used to analyze their risk factors.Results Compared with patients in group B,patients in group A had larger dose of medication,a longer time of treatment,and fewer gastric lavage cases,with statistically significant difference(x2=11.114,18.631,15.781,P＜0.05).The coagulation indexes such as prothrombin time,activated partial thromboplastin time and international normalized ratio in group A patients were significantly longer than those in group B patients(t=3.427,2.191,3.444,P＜0.05).Logistic regression results showed that timely gastric lavage was a protective factor for bleeding in patients with anticoagulant rodenticide poisoning(OR=0.033,95％CI:0.009-0.129),while late treatment time(OR=6.081,95％CI:2.326-15.658)and large dose of medication(model 1 OR=4.502,95％CI:1.447-14.004;model 2 OR=3.485,95％CI:1.183-10.268)were risk factors for bleeding in patients with anticoagulant rodenticide poisoning.Conclusion The clinical symptoms of patients with anticoagulant rodenticide poisoning are lack of specificity,mainly bleeding,which is closely related to the dosage of medication,the time of treatment and whether gastric lavage is performed.Earlier treatment and timely gastric lavage can effectively reduce the risk of bleeding,improve the clinical salvage rate,and improve the prognosis.
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