Effect of influenza vaccination on CO VID-19 and related outcomes
Objective To evaluate the impact of influenza vaccination on susceptibility to SARS-CoV-2,severity of clinical symptoms,and time to nucleic acid conversion after SARS-CoV-2 infection.Methods A survey was conducted among employees of four disease prevention and control agencies in the main urban area of Jingzhou City.A survey of influenza vaccination status and COVID-19 related status from June to November 2022 was conducted from January to March 2023 using a self-designed questionnaire.The effects of influenza vaccination on infection with SARS-CoV-2,fever symptoms of COVID-19,duration of fever of COVID-19,disease course of CO VID-19,and time of SARS-CoV-2 nucleic acid turns to negative were analyzed using binary and ordinal logistic regression.Results A total of 146 questionnaires were received,with a response rate of 52.1％.Among the respondents,95 people had been previously infected with SARS-CoV-2 and 51 people were uninfected.Seventy-two individuals were vaccinated for influenza vaccination,and 74 people were not vaccinated,and the vaccination period was from July to October.Influenza vaccination administration showed no statistically significant protective effect against COVID-19(OR=1.66,95％CI:0.74-3.84).There was no statistically significant difference in the occurrence of fever symptoms between the influenza vaccination and non-vaccination groups(OR=0.64,95％CI:0.11-3.51).Influenza vaccination did not have a significantly protective effect on reducing the duration of fever(OR=0.81,95％CI:0.29-2.23)and reducing the disease course(OR=2.44,95％CI:1.01-6.08).Influenza vaccination had no significant effect on accelerating SARS-CoV-2 nucleic acid turns to negative after COVID-19(OR=2.21,95％CI:0.45-10.80).All analyses were adjusted for age,highest education level,medical history of underlying diseases,and administration of the SARS-CoV-2 vaccination.Conclusion There is no significantly associated between influenza vaccination,infection with SARS-CoV-2,clinical symptoms of COVID-19,or time to SARS-CoV-2 nucleic acid conversion.
COVID-19SARS-CoV-2Influenza vaccineCenter for disease control and preventionProtective effect
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