Analysis of epidemiologic features and drug resistance of pulmonary tuberculosis patients in Hebei Province
Objective To understand the epidemiologic features and drug resistance of pulmonary tuberculosis patients in Hebei Province,and to provide a basis for the formulation of tuberculosis prevention and control strategy suitable for the province.Methods Descriptive epidemiological methods were used to analyze data on 1 144 patients with pulmonary tuberculosis identified to be positive for Mycobacterium tuberculosis by isolation and culture from 14 monitoring counties(districts)from January 2020 to December 2022.Results The constituent ratio of pulmonary tuberculosis patients in different genders and age groups showed statistically significant differences(x2=8.509,15.848,P=0.014,0.015),and the highest constituent ratio was found in males(74.56％)and ≥60 years age group(40.99％).A total of 1 144 positive strains were isolated cultured from pulmonary tuberculosis patients in monitored counties(districts)from 2020 to 2022,of which 1 045 cases were initially treated and 99 cases were retreated.The multidrug resistance rate was 2.58％and rifampicin resistance rate was 1.15％in initial treatment patients.The multidrug resistance rate was 6.06％and the rifampicin resistance rate was 7.07％in retreatment patients.The multidrug-resistant patients had the highest rate of resistance to"isoniazid+rifampicin,isoniazid+rifampicin+kanamycin+ofloxacin"(0.48％)in initial treatment patients,and"isoniazid+rifampicin+ethambutol"(2.06％)in retreatment patients.Conclusion Male peasants with tuberculosis,aged ≥60 years are high risk groups of drug-resistant tuberculosis,and attention should be paid to standardizing treatment in the clinic to reduce the occurrence of drug resistance.Attention should be paid to the standardized use of first-line and second-line anti-tuberculosis drugs,especially ethambutol,kanamycin,ofloxacin,moxifloxacin,to reduce the drug resistance rate.
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