Bcl－2、Bax介导肺微血管内皮细胞凋亡与神经源性肺水肿
刘雁 1彭忠田1
作者信息
- 1. 南华大学附属第一临床学院 湖南 衡阳 421001
- 折叠
摘要
近几年来手足口病在全球的发病率非常高，重症手足口病并发神经源性肺水肿（neurogenic pulmonary edema，NPE）起病急，病情发展快，病死率较高。NPE与肺微血管内皮细胞凋亡有关。Bcl－2和Bax是Bcl－2家族中与细胞凋亡关系密切的两种基因，前者为抗凋亡基因，后者为促凋亡基因。Bcl－2、Bax的表达可能与NPE的发病有关。
Abstract
In recent years,the incidence rate of hand foot and mouth disease is very high in the global,severe hand foot and mouth disease could be complicated by neurogenic pulmo-nary edema had onset nasty,il ness development quickly,high fatality rate.NPE is associated with apoptosis of pulmonary microvascular endothelial cel .Bcl-2 gene and Bax gene is closely as-sociated with apoptosis in the Bcl-2 family ,the former for antiapoptotic genes,the lat er to promote apoptosis gene.the expression of Bcl-2 gene and Bax gene may be associated with the onset of NPE.
关键词
手足口病/神经源性肺水肿/肺微血管内皮细胞/Bcl-2/BaxKey words
Hand foot and mouth disease/Neurogenic pulmonary edema/Pulmonary microvascular endothelial cel s/Bcl-2/Bax引用本文复制引用
出版年
2015
NETL
NSTL
维普
万方数据