目的：探讨临床治疗 CHOP 方案化疗所致呕吐的经济且有效的方法。方法选取我科2012－2014年期间初诊非霍奇金淋巴瘤行首次 CHOP 方案化疗的患者60例，随机分成沙利度胺组（采用沙利度胺口服治疗）及甲磺酸托烷司琼组（采用甲磺酸托烷司琼静脉推注治疗），每组30例。结果沙利度胺组止吐有效率与甲磺酸托烷司琼组相当，差异不具统计学意义（P ＞0．05）；而沙利度胺组在化疗时出现焦虑的患者明显少于甲磺酸托烷司琼组，差异具有统计学意义（P ＜0．05）。结论 CHOP 方案化疗前采用沙利度胺止吐的临床效果与采用甲磺酸托烷司琼治疗的临床效果相当，但沙利度胺更经济、临床使用更为方便，同时还有较明显缓解化疗时焦虑情绪的作用，使首次化疗患者能更加耐受 CHOP 方案化疗。
Objective:To discuss the cost -ef ective way of treating emesis caused by CHOP chemotherapy.Method:60 cases of NHL patients who received the 1st CHOP chemotherapy in our department were chosen from 2012 -2014,and divided randomly into thalidomide group(treated by thalidomide oral y)and tropisetron mesylate group(treated by tropisetron mesylate in-travenous injection),of each group was 30 cases.Results :Anti -nausea ef ect of the two groups is nearly the same,and there is no statistical y significant dif erence(P >0.05);while patients who demonstrate anxiety are obviously less in thalidomide group than those in tropisetron mesylate group,and the dif erence is of statistical significance(P <0.05).Conclusion:The anti -nausea ef ect of thalidomide and tropisetron mesylate administered before CHOP chemotherapy is nearly the same,however thalidomide is of bet er economy and more convenience for clinical,meantime thalidomide can relieve anxiety under chemotherapy more clearly,and make chemotherapy patients for the first time bet er tolerate CHOP chemotherapy.
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