口服爱维治治疗急性放射性食管炎的可行性研究
Ef ects of taking Actovegin oral y in treatment of Acute Radiation Esophagitis
高莹 1陈河润 1祝晓莲 1陈亚林1
作者信息
- 1. 北京大学人民医院放疗科 北京 100044
- 折叠
摘要
目的：探讨口服爱维治治疗急性放射性食管炎的可行性。方法76例2级以上急性食管炎患者随机分为爱维治组（42例）和常规治疗组（34例）。爱维治组每天卧位口服爱维治，常规治疗组每天口服硫糖铝。根据 CNI3．0食管炎标准进行食管炎分级，每天记录患者服药后食管炎症状变化与病变缓解时间。结果爱维治组中位缓解时间比常规治疗组短（5天 vs 10天），差异有统计学意义（P ＝0．025）。其中，2级食管炎患者，爱维治组中位缓解时间较短（5天 vs7天），差异有统计学意义（P ＝0．005）；3级食管炎患者，两组中位缓解时间没有统计学差异（15天 vs 14天，P ＝0．14）。结论口服爱维治溶液治疗急性食管炎患者可以明显缩短康复时间，尤其是对轻度的食管炎患者治疗效果明显。
Abstract
Objective:To evaluate the ef ect of taking Actovegin oral y in cureing acute radiation esophagitis.Methods:76 patients with grade two and above acute radiation esophagitis were placed into two groups:the Actovegin group(42 patients),and the control group(34 patients).Patients in the Actovegin group took Actovegin oral y on four times everyday.Patients in the control group took Sucralfate oral y on four times everyday.The grade about the acute radiation esophagitis and the time of comeback were analysed based on CNI3.0(Common Terminology Crite-ria for Adverse Events v3.0).Results:The Actovegin group had less comeback time than the control group(P =0.025).The dif erence was significant at stage Ⅱesophagitis(P =0.005),but it was not obvious at stage Ⅲesophagitis(P =0.14).Conclusions:Taking Actovegin oral y can reduce the time of comeback on patientes with acute radiation esophagitis.The curative ef ect is bet er on low grade esophagitis than high esophagitis.
关键词
放射损伤/放射性食管炎/小牛血清去蛋白提取物Key words
Radiation injuries/radiation esophagitis/Actihaemyl引用本文复制引用
出版年
2015
NETL
NSTL
维普
万方数据