摘要
目的：探讨康莱特注射液联合化疗治疗晚期非小细胞肺癌的临床疗效，为晚期非小细胞肺癌的治疗提供有效参考。方法：选取我院2012年8月～2015年1月收治的晚期非小细胞肺癌患者108例为研究对象，按照1：1比例分为对照组与观察组，各54例，2组患者均给予常规化疗治疗，观察组加用康莱特注射液联合化疗治疗，疗程结束后比较2组临床疗效及毒副反应发生情况。结果：观察组有效率为57．41％明显高于对照组33．33％（P ＜0．05）；观察组中医症候改善率为62．96％明显高于对照组的37．04％（P ＜0．05）；且毒副反应结果显示，观察组白细胞降低及胃肠道反应发生率低于对照组，差异有统计学意义（P ＜0．05）。与治疗前比较，观察组 CD3、CD4、CD8、CD4／CD8及 NKT 细胞活性均无显著差异（P ＞0．05）；对照组与治疗前比较 CD3、CD4、CD4／CD8及 NKT 细胞活性显著下降（P ＜0．05）。结论：康莱特注射液配合化疗可减轻化疗毒副反应，提高患者化疗耐受性，值得在晚期非小细胞肺癌治疗中推广和应用。
Abstract
Objective:To investigate the clinical ef ect of Kanglaite injection combined with chemotherapy in treatment of advanced non -smal cel lung cancer,to provide ef ectiverefer-ence for the treatment of advanced non -smal cel lung cancer.Methods:in our hospital from 2012 August to 2015 January were treated patients with advanced non -smal cel lung cancer in 108 cases as the research object,according to the proportion of 1:1 divided into control group and observation group,54 cases each,2 groups of patients were givenconventional chemotherapy treatment,the observation group added Kanglaite Injectioncombined with chemotherapy treatment,after the end of treatment and comparison adverse reaction of 2 groups of clinical curative ef ects occurred.Results:the observation group was 57.41% significantly higher than 33.33% in the control group (P <0.05);observation group symptom improvement rate was 62.96% signifi-cantly higher than 37.04% in the control group(P <0.05);and the toxicity results showed that the observation group,leukopenia and gastrointestinal reaction rate lower than the control group, there was statistical significancethe dif erence (P <0.05).Compared with before treatment,the observation group CD3,CD4,CD8,CD4 /CD8 and NKT cel s showed no significant dif erence (P >0.05);the control groupcompared with before treatment,CD3,CD4,CD4 /CD8 and NKT cel activity decreased significantly (P <0.05).Conclusion:Kanglaite injection combined with chemotherapy can reduce the side ef ects of chemotherapy,improve the patients'tolerance to chemotherapy and is worthy of popularization and application in advanced non smal cel lung cancer.
NETL
NSTL
维普
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