首页|The role of Down syndrome cell adhesion molecule in Down syndrome

The role of Down syndrome cell adhesion molecule in Down syndrome

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Down syndrome(DS)is caused by the presence of an extra copy of the entire or a portion of human chromosome 21(HSA21).This genomic alteration leads to elevated expression of numerous HSA21 genes,resulting in a variety of health issues in individuals with DS.Among the genes located in the DS "critical region" of HSA21,Down syndrome cell adhesion molecule(DSCAM)plays an important role in neuronal development.There is a growing body of evidence underscoring DSCAM's involve-ment in various DS-related disorders.This review aims to provide a concise overview of the established functions of DSCAM,with a particular focus on its implications in DS.We delve into the roles that DSCAM plays in DS-associated diseases.In the concluding section of this review,we explore prospective avenues for future research to further unravel DSCAM's role in DS and opportunities for thera-peutic treatments.

Down syndromeDSCAMneuronaxonGABAergic synapse

Ty Hergenreder、Tao Yang、Bing Ye

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Life Sciences Institute and Department of Cell and Developmental Biology,University of Michigan,Ann Arbor,MI,USA

Life Sciences Institute and Department of Cell and Developmental Biology,University of Michigan,210 Washtenaw Avenue,Room 5403,Ann Arbor,MI,48109,USA

2024

10.1515/mr-2023-0056

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ISSN：
年,卷(期)：2024.4(1)