医学信息学杂志2024,Vol.45Issue(4) :60-64.DOI:10.3969/j.issn.1673-6036.2024.04.010

正交偏最小二乘法探析大承气汤治疗急性胰腺炎多成分多药效关系

Exploration on the Relationship between Multi-Component and Multi-Pharmaceutical Efficacy of Treatment of Acute Pan-creatitis with Dachengqi Decoction Based on Orthogonal Partial Least Squares

聂斌 杜建强 余日跃 陈银芳 杜玉文 李海针 杨琴
医学信息学杂志2024,Vol.45Issue(4) :60-64.DOI:10.3969/j.issn.1673-6036.2024.04.010

正交偏最小二乘法探析大承气汤治疗急性胰腺炎多成分多药效关系

Exploration on the Relationship between Multi-Component and Multi-Pharmaceutical Efficacy of Treatment of Acute Pan-creatitis with Dachengqi Decoction Based on Orthogonal Partial Least Squares

聂斌 1杜建强 1余日跃 1陈银芳 1杜玉文 1李海针 1杨琴1
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作者信息

  • 1. 江西中医药大学 南昌 330004
  • 折叠

摘要

目的/意义 分析大承气汤治疗急性胰腺炎实验数据,证实多成分多药效关系.方法/过程 运用正交偏最小二乘法,分别探析配伍药味、煎煮液的药物成分、血液的药物成分与药效指标的关系.结果/结论 配伍药味与药效指标之间、煎煮液的药物成分与药效指标之间、血液的药物成分与药效指标之间均存在一对多、多对一、多对多的作用关系.实验分析结果表明大承气汤治疗急性胰腺炎呈现多成分多药效的特点.

Abstract

Purpose/Significance To analyze the experimental data of Dachengqi Decoction in treating acute pancreatitis and confirm the relationship between multi-component and multi-pharmaceutical efficacy.Method/Process The paper uses orthogonal partial least squares(OPLS)regression to analyze the relationship between the Chinese medicine compatibility,the Chinese medicine components of the decoction liquid,the Chinese medicine components of the blood and the pharmaceutical efficacy indicators respectively.Result/Con-clusion There are one-to-many,many-to-one,and many-to-many relationships between the Chinese medicine compatibility and the pharmaceutical efficacy indicators,the Chinese medicine components of the decoction liquid and the pharmaceutical efficacy indica-tors,the Chinese medicine components of the blood and the pharmaceutical efficacy indicators.The experimental results indicate that the treatment of acute pancreatitis with Dachengqi Decoction presents the characteristics of multiple components and multiple pharmaceutical efficacy.

关键词

中药成分/药效指标/正交偏最小二乘法

Key words

traditional Chinese medicine components/pharmaceutical efficacy indicators/orthogonal partial least squares

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基金项目

国家自然科学基金项目(82260849)

江西中医药大学校级科技创新团队发展计划(CXTD22015)

出版年

2024
医学信息学杂志
中国医学科学院

医学信息学杂志

CSTPCD
影响因子:1.348
ISSN:1673-6036
参考文献量21
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