首页|Solute carrier transporters: the metabolic gatekeepers of immune cells
Solute carrier transporters: the metabolic gatekeepers of immune cells
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Solute carrier (SLC) transporters meditate many essential physiological functions,including nutrient uptake,ion influx/efflux,and waste disposal.In its protective role against tumors and infections,the mammalian immune system coordinates complex signals to support the proliferation,differentiation,and effector function of individual cell subsets.Recent research in this area has yielded surprising findings on the roles of solute carrier transporters,which were discovered to regulate lymphocyte signaling and control their differentiation,function,and fate by modulating diverse metabolic pathways and balanced levels of different metabolites.In this review,we present current information mainly on glucose transporters,amino-acid transporters,and metal ion transporters,which are critically important for mediating immune cell homeostasis in many different pathological conditions.
Solute carrierLymphocytesGlucoseGlutamineMetal ion
Wenxin Song、Danyuan Li、Lei Tao、Qi Luo、Ligong Chen
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School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education), Tsinghua University, Beijing 100084, China
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100088, China
Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610065, China
This research was supported by Nation Science and Technology Major Projects for Major New Drugs Innovation and DevelopmentThis research was supported by Nation Science and Technology Major Projects for Major New Drugs Innovation and DevelopmentMinistry of Science and Technology of China National Key R&D Programs
2018ZX09711003-004-002 to Ligong ChenChina2018YFA050690
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NSTL
维普
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