首页|Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression

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Bone diseases such as osteoporosis and periodontitis are induced by excessive osteoclastic activity,which is closely associated with inflammation.Benzydamine (BA) has been used as a cytokine-suppressive or non-steroidal anti-inflammatory drug that inhibits the production of proinflammatory cytokines or prostaglandins.However,its role in osteoclast differentiation and function remains unknown.Here,we explored the role of BA in regulating osteoclast differentiation and elucidated the underlying mechanism.BA inhibited osteoclast differentiation and strongly suppressed interleukin-1β (IL-1β) production.BA inhibited osteoclast formation and bone resorption when added to bone marrowderived macrophages and differentiated osteoclasts,and the inhibitory effect was reversed by IL-1β treatment.The reporter assay and the inhibitor study of IL-1β transcription suggested that BA inhibited nuclear factor-κB and activator protein-1 by regulating IκB kinase,extracellular signal regulated kinase and P38,resulting in the down-regulation of IL-1β expression.BA also promoted osteoblast differentiation.Furthermore,BA protected lipopolysaccharide-and ovariectomy-induced bone loss in mice,suggesting therapeutic potential against inflammation-induced bone diseases and postmenopausal osteoporosis.

BenzydamineOsteoclastBoneInterleukin-1βNuclear factor-κBActivator protein-1

Han Saem Son、Jiae Lee、Hye In Lee、Narae Kim、You-Jin Jo、Gong-Rak Lee、Seong-Eun Hong、Minjeong Kwon、Nam Young Kim、Hyun Jin Kim、Jin Ha Park、Soo Young Lee、Woojin Jeong

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Department of Life Science and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, South Korea

This work was supported by the National Research Foundation (NRF)This work was supported by the National Research Foundation (NRF)Korean Ministry of Science,ICT and future Planning (MSIP)

2019R1A5A6099645Korea

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(3)
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