Targeting autophagy-related protein kinases for potential therapeutic purpose

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外文摘要：Autophagy,defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes,plays a significant role in the quality control of macromolecules and organelles.Since protein kinases are integral to the autophagy process,it is critically important to understand the role of kinases in autophagic regulation.At present,intervention of autophagic processes by small-molecule modulators targeting specific kinases has becoming a reasonable and prevalent strategy for treating several varieties of human disease,especially cancer.In this review,we describe the role of some autophagy-related kinase targets and kinase-mediated phosphorylation mechanisms in autophagy regulation.We also summarize the small-molecule kinase inhibitors/activators of these targets,high-lighting the opportunities of these new therapeutic agents.

外文关键词：

AutophagyProtein kinasesAutophagy-related kinasePhosphorylationSmall-molecule kinase inhibitors/activatorsHuman disease therapy

作者：

Honggang Xiang、Jifa Zhang、Congcong Lin、Lan Zhang、Bo Liu、Liang Ouyang

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作者单位：

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China

基金：

This work was supported by grants from National Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

项目编号：

2017YFC090930281903502the Opening Foundation of Stat

出版年：

2020

药学学报(英文版)

CSTPCDCSCDSCI

ISSN：

年,卷(期)：2020.10(4)

被引量29
参考文献量3