首页|Natural products, PGC-1α, and Duchenne muscular dystrophy

Natural products, PGC-1α, and Duchenne muscular dystrophy

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Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that binds to a diverse range of transcription factors.PPARγ coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial biogenesis.Owing to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases.Among these,some evidence has shown that various signaling pathways linked to PGC-1α are deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production.In the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies.PGC-1α is influenced by different patho-physiological/pharmacological stimuli.Natural products have been reported to display modulatory effects on PPARγ activation with fewer side effects in comparison to synthetic drugs.Taken together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.

Muscular dystrophyNatural productPeroxisome proliferator-activated receptor γ coactivator 1αPPARγ activationReactive oxygen speciesMitochondrial oxidative phosphorylation

Ipek Suntar、Antoni Sureda、Tarun Belwal、Ana Sanches Silva、Rosa Anna Vacca、Devesh Tewari、Eduardo Sobarzo-Sánchez、Seyed Fazel Nabavi、Samira Shirooie、Ahmad Reza Dehpour、Suowen Xu、Bahman Yousefi、Maryam Majidinia、Maria Daglia、Giuseppe D'Antona、Seyed Mohammad Nabavi

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Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, Turkey

Research Group in Community Nutrition and Oxidative Stress, Health Research Institute of the Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, Palma,Balearic Islands E-07122, Spain

G.B.Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora,Uttarakhand 263643, India

National Institute for Agricultural and Veterinary Research (INIAV), Vair(a)o, Vila do Conde, Portugal

Center for Study in Animal Science (CECA), ICETA, University of Porto, Porto, Portugal

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari 70126, Italy

Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara,Punjab 144411, India

Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain

Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 5613156491, Iran

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences,Kermanshah 6715847141, Iran

Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran 1416753955, Iran

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz 516615731, Iran

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 516615731, Iran

Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia 571478334, Iran

Department of Pharmacy, University of Naples Federico Ⅱ, Naples 80138, Italy

International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China

Department of Public Health, Experimental and Forensic Medicine and CRIAMS-Sport Medicine Centre,University of Pavia, Pavia 27100, Italy

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crowd funding Sport4Therapy to Giuseppe D'Antona (Italy)ASureda was supported by Instituto de Salud Carlos Ⅲ,Grant Number: C

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(5)
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