首页|Self-assembled small molecule natural product gel for drug delivery: a breakthrough in new application of small molecule natural products

Self-assembled small molecule natural product gel for drug delivery: a breakthrough in new application of small molecule natural products

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Natural products,as a gift of nature to humanity,have long been used as drugs or pharmacological actives to help people cure various diseases.Yet we still know comparatively little about their ability to be materials.In recent years,some small molecule natural products isolated from traditional Chinese medicines have been found to have new features,namely,self-assembly to form gels (i.e.,natural product gels,NPG).However,the application development of these natural products is seriously lacking,which greatly weakens their practical value and delays the maturity of the field.Here,a series of self-assembled triterpenoid natural products are used as materials (gel scaffolds) to construct drug delivery systems.Surprisingly,these NPG not only exhibit the excellent self-healing,controlled gelation,good safety and sustained release,but also achieve synergistic treatment of tumors through bioactive natural products.Compared with non-bioactive gel scaffolds,NPG scaffolds show great advantages in tumor therapy,including optimal tumor inhibition,preferable health,better body recovery,stronger immune function,less toxic side effects and longer survival.The successful construction of NPG scaffolds not only takes full advantage of the self-assembled natural products,but also takes an important step in the development of new applications for natural products.

Natural productsGelsSelf-assemblyDrug deliveryAntitumor

Kangkang Zhi、Jiacheng Wang、Haitian Zhao、Xin Yang

展开 >

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150000, China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHeilongjiang provincial financial support project (Xin Yang),and Harbin Special Foundation for Excellent Academic Leader ProjectHeilongjiang provincial financial support project (Xin Yang),and Harbin Special Foundation for Excellent Academic Leader Project

Nos3197204031571798No2014RFXXJ113China

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(5)
  • 3
  • 1