Bioactive natural compounds against human coronaviruses: a review and perspective

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外文摘要：Coronaviruses (CoVs),a family of enveloped positive-sense RNA viruses,are characterized by club-like spikes that project from their surface,unusually large RNA genome,and unique replication capability.CoVs are known to cause various potentially lethal human respiratory infectious diseases,such as severe acute respiratory syndrome (SARS),Middle East respiratory syndrome (MERS),and the very recent coronavirus disease 2019 (COVID-19) outbreak.Unfortunately,neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs.Therefore,effective prevention and treatment medications against human coronavirus are in urgent need.In the past decades,many natural compounds have been reported to possess multiple biological activities,including antiviral properties.In this article,we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS,and discussed their potential use for the treatment of COVID-19.

外文关键词：

Natural compoundsCoronavirusRNA-VirusMERS-CoVSARS-CoVSARS-CoV-2COVID-19

作者：

Yanfang Xian、Juan Zhang、Zhaoxiang Bian、Hua Zhou、Zhenbiao Zhang、Zhixiu Lin、Hongxi Xu

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作者单位：

School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR,China

Brain Research Centre, School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong,Hong Kong SAR, China

Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China

Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Hong Kong Institute of Integrative Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

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出版年：

2020

药学学报(英文版)

CSTPCDCSCDSCI

ISSN：

年,卷(期)：2020.10(7)

被引量8
参考文献量5