首页|Efficient drug and gene delivery to liver fibrosis:rationale, recent advances, and perspectives

Efficient drug and gene delivery to liver fibrosis:rationale, recent advances, and perspectives

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Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix,and no specific medical therapy is approved for that until now.Due to liver metabolic capacity for drugs,the fragility of drugs,and the presence of insurmountable physiological obstacles in the way of targeting,the development of efficient drug delivery systems for anti-fibrotics seems vital.We have explored articles with a different perspective on liver fibrosis over the two decades,then collected and summarized the information by providing corresponding in vitro and in vivo cases.We have discussed the mechanism of hepatic fibrogenesis with different ways of fibrosis induction in animals.Furthermore,the critical chemical and herbal anti-fibrotics,biological molecules such as micro-RNAs,siRNAs,and growth factors,which can affect cell division and differentiation,are mentioned.Likewise,drug and gene delivery and therapeutic systems on in vitro and in vivo models are summarized in the data tables.This review article enlightens recent advances in emerging drugs and nanocarriers and represents perspectives on targeting strategies employed in liver fibrosis treatment.

Liver fibrosisHepatic stellate cellDrug deliveryGene therapyLipid nanoparticleViral and non-viral vectorHerbal anti-fibrotic

Somayeh Mahdinloo、Seyed Hossein Kiaie、Ala Amiri、Salar Hemmati、Hadi Valizadeh、Parvin Zakeri-Milani

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Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz 5166616471, Iran

Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah 6715847141,Iran

Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch, Tehran 1477893855,Iran

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran

Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran

Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran

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We gratefully thank the financial support of Tabriz University of Medical Science (Iran)This article is based on a PhD thesis (D

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(7)
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