首页|Novel approach for real-time monitoring of carrier-based DPIs delivery process via pulmonary route based on modular modified Sympatec HELOS

Novel approach for real-time monitoring of carrier-based DPIs delivery process via pulmonary route based on modular modified Sympatec HELOS

扫码查看
原文链接
  • NETL
  • NSTL
  • 维普
  • 万方数据
An explicit illustration of pulmonary delivery processes (PDPs) was a prerequisite for the formulation design and optimization of carrier-based DPIs.However,the current evaluation approaches for DPIs could not provide precise investigation of each PDP separately,or the approaches merely used a simplified and idealized model.In the present study,a novel modular modified Sympatec HELOS (MMSH) was developed to fully investigate the mechanism of each PDP separately in real-time.An inhaler device,artificial throat and pre-separator were separately integrated with a Sympatec HELOS.The dispersion and fluidization,transportation,detachment and deposition processes of pulmonary delivery for model DPIs were explored under different flow rates.Moreover,time-sliced measurements were used to monitor the PDPs in real-time.The Next Generation Impactor (NGI) was applied to determine the aerosolization performance of the model DPIs.The release profiles of the drug particles,drug aggregations and carriers were obtained by MMSH in real-time.Each PDP of the DPIs was analyzed in detail.Moreover,a positive correlation was established between the total release amount of drug particles and the fine particle fraction (FPF) values (R2 =0.9898).The innovative MMSH was successfully developed and was capable of illustrating the PDPs and the mechanism of carrier-based DPIs,providing a theoretical basis for the design and optimization of carrier-based DPIs.

Dry powder inhalationPulmonary delivery processReal-time monitoringModular modificationCartierAir flow rateMechanism of drug delivery

Xuejuan Zhang、Yingtong Cui、Ruifeng Liang、Guanlin Wang、Xiao Yue、Ziyu Zhao、Zhengwei Huang、Ying Huang、Jianfang Geng、Xin Pan、Chuanbin Wu

展开 >

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

Institute for Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006,China

Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China

School of Pharmaceutical Science, Jinan University, Guangzhou 510006, China

Sympatec GmbH Suzhou Rep.Office, Suzhou 215123, China

展开 >

This paper was funded by the National Natural Science Foundation of ChinaThis paper was funded by the National Natural Science Foundation of ChinaScience and Technology Foundation GuangzhouScience and Technology Foundation Guangzhouand the National Students Innovation Training Program of China

8167337581703431201509030006China201901390The authors th

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(7)
  • 3
  • 1