首页|Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

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Cancer immunotherapy has veered the paradigm of cancer treatment.Despite recent ad-vances in immunotherapy for improved antitumor efficacy,the complicated tumor microenvironment(TME)is highly immunosuppressive,yielding both astounding and unsatisfactory clinical successes.In this regard,clinical outcomes of currently available immunotherapy are confined to the varied immune systems owing in large part to the lack of understanding of the complexity and diversity of the immune context of the TME.Various advanced designs of nanomedicines could still not fully surmount the de-livery barriers of the TME.The immunosuppressive TME may even dampen the efficacy of antitumor immunity.Recently,some nanotechnology-related strategies have been inaugurated to modulate the immunosuppressive cells within the tumor immune microenvironment(TIME)for robust immunothera-peutic responses.In this review,we will highlight the current understanding of the immunosuppressive TIME and identify disparate subclasses of TIME that possess an impact on immunotherapy,especially those unique classes associated with the immunosuppressive effect.The immunoregulatory cell types in-side the immunosuppressive TIME will be delineated along with the existing and potential approaches for immunosuppressive cell modulation.After introducing the various strategies,we will ultimately outline both the novel therapeutic targets and the potential issues that affect the efficacy of TIME-based nano-medicines.

Cancer immunotherapyNanomedicineTumor immunosuppressive microenvironmentDrug delivery

Yuefei Zhu、Xiangrong Yu、Soracha D. Thamphiwatana、Ying Zheng、Zhiqing Pang

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Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA

Key Laboratory of Smart Drug Delivery, School of Pharmacy, Fudan University, Ministry of Education, Shanghai 201203, China

Department of Medical Imaging, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University,Zhuhai 519000, China

Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom 73170,Thailand

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China

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authors are grateful to the financial support from the National Natural Science Foundation of Chinaauthors are grateful to the financial support from the National Natural Science Foundation of China

8177328381701684

2020

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2020.10(11)
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