首页|Inhibitory effects of baicalein against herpes simplex virus type 1

Inhibitory effects of baicalein against herpes simplex virus type 1

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Herpes simplex virus type 1(HSV-1)is a ubiquitous and widespread human pathogen,which gives rise to a range of diseases,including cold sores,corneal blindness,and encephalitis.Currently,the use of nucleoside analogs,such as acyclovir and penciclovir,in treating HSV-1 infection often presents limi-tation due to their side effects and low efficacy for drug-resistance strains.Therefore,new anti-herpetic drugs and strategies should be urgently developed.Here,we reported that baicalein,a naturally derived compound widely used in Asian countries,strongly inhibited HSV-1 replication in several models.Baica-lein was effective against the replication of both HSV-1/F and HSV-1/Blue(an acyclovir-resistant strain)in vitro.In the ocular inoculation mice model,baicalein markedly reduced in vivo HSV-1/F replication,receded inflammatory storm and attenuated histological changes in the cornea.Consistently,baicalein was found to reduce the mortality of mice,viral loads both in nose and trigeminal ganglia in HSV-1 intra-nasal infection model.Moreover,an ex vivo HSV-1-EGFP infection model established in isolated murine epidermal sheets confirmed that baicalein suppressed HSV-1 replication.Further investigations unraveled that dual mechanisms,inactivating viral particles and inhibiting IκB kinase beta(IKK-β)phosphorylation,were involved in the anti-HSV-1 effect of baicalein.Collectively,our findings identified baicalein as a promising therapy candidate against the infection of HSV-1,especially acyclovir-resistant strain.

Anti-HSV-1BaicaleinViral inactivationIKK-β phosphorylationNF-κB activationHSV-1 infection

Zhuo Luo、Xiu-Ping Kuang、Qing-Qing Zhou、Chang-Yu Yan、Wen Li、Hai-Biao Gong、Hiroshi Kurihara、Wei-Xi Li、Yi-Fang Li、Rong-Rong He

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Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility,College of Pharmacy,College of Pharmacy,Jinan University,Guangzhou 612505,China

International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE),College of Pharmacy,Jinan University,Guangzhou 612505,China

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Gu

Yunnan University of Traditional Chinese Medicine,Kunming 650550,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaLocal Innovative and Research Teams Project of Guangdong Pearl River Talents ProgramLocal Innovative and Research Teams Project of Guangdong Pearl River Talents ProgramLocal Innovative and Research Teams Project of Guangdong Pearl River Talents ProgramLocal Innovative and Research Teams Project of Guangdong Pearl River Talents ProgramGuangdong Science and Tech-nology FoundationProgram of Hong Kong ScholarProgram of Hong Kong ScholarScience and Technology Program of GuangzhouScience and Technology Program of GuangzhouYouth Top-notch Talent Support Program of Guangdong ProvinceYouth Top-notch Talent Support Program of Guangdong Province

U1801284815736758162205081873209816737092017YFC17004042017BT01Y036ChinaGDUPS2019China2017A030306004XJ2016017China201903010062China2016TQ03R586China

2020

药学学报(英文版)

药学学报(英文版)

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ISSN：
年,卷(期)：2020.10(12)
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