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Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

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Pharmaceutical analysis is a discipline based on chemical,physical,biological,and informa-tion technologies.At present,biotechnological analysis is a short branch in pharmaceutical analysis;how-ever,bioanalysis is the basis and an important part of medicine.Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety,which are important characteris-tics of drug quality.Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results,some biotechnological analysis methods have been grad-ually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding,DNA-based rapid detection,multiplex ligation-dependent probe ampli-fication,hyperspectral imaging combined with artificial intelligence,3D biologically printed organoids,omics-based artificial intelligence,microfluidic chips,organ-on-a-chip,signal transduction pathway-related reporter gene assays,and the zebrafish thrombosis model.The applications of these emerging bio-techniques in pharmaceutical analysis have been discussed in this review.

BiotechnologyPharmaceutical analysisRaw materialsManufacturing controlQuality analysis

Shilin Chen、Zheng Li、Sanyin Zhang、Yuxin Zhou、Xiaohe Xiao、Pengdi Cui、Binjie Xu、Qinghe Zhao、Shasha Kong、Yuntao Dai

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Institute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China

Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

State Key Laboratory of Component Traditional Chinese Medicine,College of Pharmaceutical Engineering of Traditional Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China

China Military Institute of Chinese Medicine,Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China

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国家重点研发计划国家自然科学基金

2019YFC1711100U1812403-1

2022

药学学报(英文版)

药学学报(英文版)

CSTPCDCSCDSCI
ISSN：
年,卷(期)：2022.12(11)
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