Traditional Chinese medicine for the treatment of immune-related nephropathy:A review

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外文摘要：Immune-related nephropathy(IRN)refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal failure.The pathogenesis of IRN is not fully understood;there-fore,treatment is challenging.Traditional Chinese medicines(TCMs)have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy,lupus nephropathy,and diabetic ne-phropathy.The underlying mechanisms mainly include its inhibition of inflammation;improvements to renal interstitial fibrosis,oxidative stress,autophagy,apoptosis;and regulation of immunity.In this re-view,we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions,herbs,and bioactive compounds in treating IRN,as well as the potential mechanisms,intending to pro-vide a reference for the future study of TCM as IRN treatments.

外文关键词：

IgA nephropathyDiabetic nephropathyLupus nephritisTraditional Chinese medicineImmunityPathogenesisMechanismPathophysiology

作者：

Pu Jiang、Changliang Yao、De-an Guo

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作者单位：

School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

Shanghai Research Center for Modernization of Traditional Chinese Medicine,National Engineering Research Center of TCM Standardization Technology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

基金：

Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine(2020)国家自然科学基金国际(地区)合作与交流重点项目国家自然科学基金Bing Han,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou,China,for his valuable inputs on scienti

项目编号：

8213011132141005

出版年：

2024

DOI：

10.1016/j.apsb.2023.11.006

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(1)

参考文献量179