Emerging delivery systems based on aqueous two-phase systems:A review

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外文摘要：The aqueous two-phase system(ATPS)is an all-aqueous system fabricated from two immis-cible aqueous phases.It is spontaneously assembled through physical liquid-liquid phase separation(LLPS)and can create suitable templates like the multicompartment of the intracellular environment.Delicate structures containing multiple compartments make it possible to endow materials with advanced functions.Due to the properties of ATPSs,ATPS-based drug delivery systems exhibit excellent biocom-patibility,extraordinary loading efficiency,and intelligently controlled content release,which are partic-ularly advantageous for delivering drugs in vivo.Therefore,we will systematically review and evaluate ATPSs as an ideal drug delivery system.Based on the basic mechanisms and influencing factors in form-ing ATPSs,the transformation of ATPSs into valuable biomaterials is described.Afterward,we concen-trate on the most recent cutting-edge research on ATPS-based delivery systems.Finally,the potential for further collaborations between ATPS-based drug-carrying biomaterials and disease diagnosis and treat-ment is also explored.

外文关键词：

Aqueous two-phase systemsDrug delivery systemsBiomaterialsMicrocapsulesMicroparticlesCell therapyCancer treatmentOrgan regeneration

作者：

Yaowen Zhang、Yankun Luo、Jingqi Zhao、Wenzhuo Zheng、Jun Zhan、Huaping Zheng、Feng Luo

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作者单位：

State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China School of Stomatology,Sichuan University,Chengdu 610041,China

Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu 610041,China

Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China

Department of Dermatology,Rare Diseases Center,Institutes for Systems Genetics,Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,China

Department of Prosthodontics,West China School of Stomatology,Sichuan University,Chengdu 610041,China

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基金：

National Natural Science Foundation of China Youth Science Fund ProjectApplied Basic Research Project of Sichuan province

项目编号：

820011072022NSFSC1345

出版年：

2024

DOI：

10.1016/j.apsb.2023.08.024

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(1)

参考文献量157