首页|Advanced nano-based strategies for mRNA tumor vaccine

Advanced nano-based strategies for mRNA tumor vaccine

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Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor an-tigens into the body to activate specific anti-tumor immune responses.Along with the technological breakthroughs in genetic engineering and delivery systems,messenger ribonucleic acid(mRNA)technol-ogy has achieved unprecedented development and application over the last few years,especially the emergency use authorizations of two mRNA vaccines during the COVID-19 pandemic,which has saved countless lives and makes the world witness the powerful efficacy of mRNA technology in vaccines.However,unlike infectious disease vaccines,which mainly induce humoral immunity,tumor vaccines also need to activate potent cellular immunity to control tumor growth,which creates a higher demand for mRNA delivery to the lymphatic organs and antigen-presenting cells(APCs).Here we review the ex-isting bottlenecks of mRNA tumor vaccines and advanced nano-based strategies to overcome those chal-lenges,as well as future considerations of mRNA tumor vaccines and their delivery systems.

mRNA vaccineNanoparticleTumor vaccineDelivery systemStabilityTargetingTransfectionImmunogenicity

Yangqi Qu、Jingjing Xu、Tong Zhang、Qinjun Chen、Tao Sun、Chen Jiang

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Key Laboratory of Smart Drug Delivery(Ministry of Education),Minhang Hospital,State Key Laboratory of Medical Neurobiology,Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203,China

National Natural Science Funds of ChinaNational Natural Science Funds of ChinaDevelopment Fund for Shanghai TalentsNatural Science Foundation of Shanghai Science and Technology Innovation PlanFDU 2025-Excellence Program Fund,Project Supported by Shanghai Municipal Science and Technology Major ProjectZJLab,Shanghai Postdoctoral Excellence Program中国博士后科学基金

9205911081872808202009022ZR14141002018SHZDZX0120330162023M730711

2024

10.1016/j.apsb.2023.07.025

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(1)
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