首页|Visualization of nasal powder distribution using biomimetic human nasal cavity model

Visualization of nasal powder distribution using biomimetic human nasal cavity model

扫码查看
原文链接
  • 万方数据
  • 维普
Nasal drug delivery efficiency is highly dependent on the position in which the drug is depos-ited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug pow-ders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device's performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution pat-terns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the poten-tial to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

Nasal drug depositionNasal drug distributionNasal drug deliveryBiomimetic nasal modelNasal powderThree-dimensional reconstructionThree-dimensional printingNasal drug distribution visualization

Jiawen Su、Yan Liu、Hongyu Sun、Abid Naeem、Huipeng Xu、Yue Qu、Caifen Wang、Zeru Li、Jianhua Lu、Lulu Wang、Xiaofeng Wang、Jie Wu、Lixin Sun、Jiwen Zhang、Zhigang Wang、Rui Yang、Li Wu

展开 >

Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China

Yangtze Delta Drug Advanced Research Institute,Nantong 226126,China

Shenyang Pharmaceutical University,Shenyang 110016,China

Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201210,China

Nanjing University of Chinese Medicine,Nanjing 210023,China

Nantong Haimen People's Hospital,Nantong 226199,China

National Institutes for Food and Drug Control,Beijing 100000,China

Key Laboratory of Molecular Pharmacology and Drug Evaluation,School of Pharmacy,Ministry of Education,Yantai University,Yantai 264005,China

展开 >

Key Program for International Science and Technology Cooperation Projects of ChinaInnovation Leading Talents Shortterm Program of Jiangxi Province,ChinaShanghai Science and Technology Plan

2020YFE0201700126200010221DZ2260400

2024

10.1016/j.apsb.2023.06.007

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(1)
  • 39