Development of Chinese herbal medicine for sensorineural hearing loss

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外文摘要：According to the World Health Organization's world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on in-dividual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accu-mulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in un-derstanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demon-strated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.

外文关键词：

Sensorineural hearing lossChinese herbal medicineMolecular mechanismActive ingredientsPrescriptionsOtotoxic drugsNoiseHair cells

作者：

Yunhao Wu、Jingwen Zhang、Qiuping Liu、Zhuang Miao、Renjie Chai、Wenyong Chen

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作者单位：

State Key Laboratory of Bioelectronics,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China

Department of Otolaryngology-Head and Neck,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China

Department of Otolaryngology-Head and Neck Surgery,Affiliated Hospital of Jiangnan University,Wuxi 214000,China

Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610000,China

Co-Innovation Center of Neuroregeneration,Nantong Un

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基金：

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Key R&D Program of ChinaStrategic Priority Research Program of the Chinese Academy of Science,ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Department of Sichuan Province,ChinaShenzhen Science and Technology Program,ChinaShenzhen Science and Technology Program,ChinaOpen Research Fund of State Key Laboratory of Genetic Engineering,Fudan University,China

项目编号：

2021YFA11013002021YFA11018002020YFA0112503XDA16010303821012288203002981970882921493042021YFS0371JCYJ20190814093401920JCYJ20210324125608022SKLGE-2104

出版年：

2024

DOI：

10.1016/j.apsb.2023.11.001

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(2)

参考文献量122