Evolution of chemistry and selection technology for DNA-encoded library

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外文摘要：DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the non-self-replicating chemical phenotypes,generating a diverse chemical world.In analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical phenotypes.Importantly,DNA-compatible synthesis is the key to expanding the DEL chemical space.Besides,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection strategies.In this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.

外文关键词：

DNA-encoded libraryDrug discoveryHigh-throughput selectionDNA-compatible synthesisIn vitro evolutionChemical central dogma

作者：

Peixiang Ma、Shuning Zhang、Qianping Huang、Yuang Gu、Zhi Zhou、Wei Hou、Wei Yi、Hongtao Xu

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作者单位：

Shanghai Key Laboratory of Orthopedic Implants,Department of Orthopedics,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200025,China

Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai 201210,China

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology,The NMPA and State Key Laboratory of Respiratory Disease,Guangzhou Medical University,Guangzhou 511436,China

College of Pharmaceutical Science and Institute of Drug Development & Chemical Biology,Zhejiang University of Technology,Hangzhou 310014,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Shanghai,ChinaNatural Science Foundation of Shanghai,ChinaNatural Science Foundation of Zhejiang Province,ChinaShanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal SystemShanghai Key Laboratory of Orthopedic Implants,China

项目编号：

numbers 221770732197707021907085U19A2011numbers 21ZR144290023ZR1437600LY22H300001KFKT202207

出版年：

2024

DOI：

10.1016/j.apsb.2023.10.001

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(2)

参考文献量162