Lipid nanovehicles overcome barriers to systemic RNA delivery:Lipid components,fabrication methods,and rational design

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外文摘要：Lipid nanovehicles are currently the most advanced vehicles used for RNA delivery,as demon-strated by the approval of patisiran for amyloidosis therapy in 2018.To illuminate the unique superiority of lipid nanovehicles in RNA delivery,in this review,we first introduce various RNA therapeutics,describe systemic delivery barriers,and explain the lipid components and methods used for lipid nanovehicle prep-aration.Then,we emphasize crucial advances in lipid nanovehicle design for overcoming barriers to sys-temic RNA delivery.Finally,the current status and challenges of lipid nanovehicle-based RNA therapeutics in clinical applications are also discussed.Our objective is to provide a comprehensive over-view showing how to utilize lipid nanovehicles to overcome multiple barriers to systemic RNA delivery,inspiring the development of more high-performance RNA lipid nanovesicles in the future.

外文关键词：

Lipid nanovehiclesRNA therapeuticsBarriers to systemic RNA deliveryLipid componentsFabrication methodsLipid nanovehicle designExtrahepatic tissue targetingOrgan tropism

作者：

Jing Yan、Hao Zhang、Guangfeng Li、Jiacan Su、Yan Wei、Can Xu

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作者单位：

Institute of Translational Medicine,Shanghai University,Shanghai 200444,China

Institute of Medicine,Shanghai University,Shanghai 200444,China

Department of Orthopedics,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

Department of Orthopedics,Shanghai Zhongye Hospital,Shanghai 200941,China

Organoid Research Center,Shanghai University,Shanghai 200444,China

Department of Gastroenterology,Changhai Hospital,Shanghai 200433,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Municipal Natural Science Foundation

项目编号：

8217209881872428817030108220234423ZR1463300

出版年：

2024

DOI：

10.1016/j.apsb.2023.10.012

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(2)

参考文献量176