首页|Targeting the Warburg effect:A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Targeting the Warburg effect:A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

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Cancer reprogramming is an important facilitator of cancer development and survival,with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation,even under sufficient oxygen supply condition.This metabolic alteration,known as the Warburg effect,serves as a significant indicator of malignant tumor transformation.The Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer cells.Key enzymes involved in this process include glucose transporters(GLUTs),HKs,PFKs,LDHs,and PKM2.Moreover,the expression of transcriptional regulatory factors and proteins,such as FOXM1,p53,NF-κB,HIF1α,and c-Myc,can also influence cancer progression.Furthermore,lncRNAs,miRNAs,and circular RNAs play a vital role in directly regulating the Warburg effect.Additionally,gene mutations,tumor microenvironment remodeling,and immune system interactions are closely associated with the Warburg effect.Notably,the development of drugs targeting the Warburg effect has exhibited promising potential in tumor treatment.This comprehensive review presents novel directions and approaches for the early diagnosis and treatment of cancer patients by conducting in-depth research and summarizing the bright prospects of targeting the Warburg effect in cancer.

Warburg effectCancerRegulatory factorLncRNAsmiRNAsTraditional Chinese medicineSmall-molecule drugDrug resistance

Minru Liao、Dahong Yao、Lifeng Wu、Chaodan Luo、Zhiwen Wang、Jin Zhang、Bo Liu

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Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

School of Pharmaceutical Sciences,Shenzhen Technology University,Shenzhen 518118,China

Department of Psychology,University of Southern California,Los Angeles,CA 90089,USA

School of Pharmacy,Shenzhen University Medical School,Shenzhen University,Shenzhen 518055,China

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国家自然科学基金国家自然科学基金国家自然科学基金Shenzhen science and technology research and development funds

821726498200358082173666JCYJ20210324094612035

2024

10.1016/j.apsb.2023.12.003

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(3)
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