首页|Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

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Cancer remains one of the diseases with the highest incidence and mortality globally.Con-ventional treatment modalities have demonstrated threatening drawbacks including invasiveness,non-controllability,and development of resistance for some,including chemotherapy,radiation,and surgery.Sono-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment mo-dality which offers a non-invasive and controllable therapeutic approach.SPDT combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer eradication.The use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and PDT.This review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

Sonodynamic therapyPhotodynamic therapyCombinatorial therapyPhthalocyaninesSensitizerCancer

Lindokuhle Cindy Nene、Heidi Abrahamse

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Laser Research Centre,Faculty of Health Sciences,University of Johannesburg,Doornfontein 2028,South Africa

National Research Foundation of South AfricaSouth African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of Sou

98337

2024

10.1016/j.apsb.2023.11.030

药学学报(英文版)

药学学报(英文版)

CSTPCD
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年,卷(期)：2024.14(3)
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