Towards overcoming obstacles of type Ⅱ photodynamic therapy:Endogenous production of light,photosensitizer,and oxygen

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外文摘要：Conventional photodynamic therapy(PDT)approaches face challenges including limited light penetration,low uptake of photosensitizers by tumors,and lack of oxygen in tumor microenviron-ments.One promising solution is to internally generate light,photosensitizers,and oxygen.This can be accomplished through endogenous production,such as using bioluminescence as an endogenous light source,synthesizing genetically encodable photosensitizers in situ,and modifying cells genetically to ex-press catalase enzymes.Furthermore,these strategies have been reinforced by the recent rapid advance-ments in synthetic biology.In this review,we summarize and discuss the approaches to overcome PDT obstacles by means of endogenous production of excitation light,photosensitizers,and oxygen.We envi-sion that as synthetic biology advances,genetically engineered cells could act as precise and targeted"living factories"to produce PDT components,leading to enhanced performance of PDT.

外文关键词：

Photodynamic therapyCancerBiogenesisBiosynthesisEngineered bacteriaPhototherapyPhotosensitizersCatalase

作者：

Lin Yu、Zhen Liu、Wei Xu、Kai Jin、Jinliang Liu、Xiaohui Zhu、Yong Zhang、Yihan Wu

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作者单位：

Department of Chemical and Environmental Engineering,Shanghai University,Shanghai 200433,China

School of Medicine,Shanghai University,Shanghai 200433,China

Department of Biomedical Engineering,City University of Hong Kong,Hong Kong,China

基金：

国家自然科学基金

项目编号：

32000036

出版年：

2024

DOI：

10.1016/j.apsb.2023.11.007

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(3)

参考文献量173