首页|Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

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Cancer,a complex and heterogeneous disease,arises from genomic instability.Currently,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clin-ical practice.However,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical demands.Metal nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer therapy.Their customizable physico-chemical properties enable the development of targeted and personalized treatment platforms.In this re-view,we delve into the design principles and optimization strategies of metal nanoparticles.We shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal nanoparticles.These encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune response.Moreover,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle platforms.Finally,we present insights into the challenges and future direc-tions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

DNA damageMetal nanoparticlesNucleus-targetingDNA repair inhibitionImmune responseSize optimizationStimuli-responsivenessSurface modification

Qian Chen、Chunyan Fang、Fan Xia、Qiyue Wang、Fangyuan Li、Daishun Ling

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Institute of Pharmaceutics,Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China

World Laureates Association(WLA)Laboratories,Shanghai 201203,China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Pr

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国家重点研发计划国家重点研发计划国家重点研发计划Leading Talent of"Ten Thousand Plan"-National High-Level Talents Special Support Plan国家自然科学基金国家自然科学基金Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action PlanProgram of Shanghai Science and Technology Development浙江省自然科学基金浙江省自然科学基金Innovative Research Team of High-Level Local Universities in Shanghai中国科学院跨学科创新团队项目

2022YFB32038042022YFB32038012022YFB3203800320713743200098521XD142210022TS1400700LR22C100001LQ21H300003SHSMU-ZDCX20210900JCTD-2020-08

2024

10.1016/j.apsb.2023.08.031

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(3)
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