首页|Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

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Aging increases the risks of various diseases and the vulnerability to death.Cellular senes-cence is a hallmark of aging that contributes greatly to aging and aging-related diseases.This study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in vivo.The intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging mice.The anti-aging effects of USC-EVs are not obviously affected by the USC donors'ages,genders,or health status.Proteomic analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue in-hibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins.

Extracellular vesiclesUrine-derived stem cellsCellular senescenceAnti-agingPLAUTIMP1Senescence-accelerated miceNatural aging mice

Shanshan Rao、Zehui He、Zun Wang、Hao Yin、Xiongke Hu、Yijuan Tan、Tengfei Wan、Hao Zhu、Yi Luo、Xin Wang、Hongming Li、Zhenxing Wang、Xinyue Hu、Chungu Hong、Yiyi Wang、Mingjie Luo、Wei Du、Yuxuan Qian、Siyuan Tang、Hui Xie、Chunyuan Chen

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Department of Orthopedics,Movement System Injury and Repair Research Center,Xiangya Hospital,Central South University,Changsha 410008,China

Hunan Key Laboratory of Angmedicine,Changsha 410008,China

Xiangya School of Nursing,Central South University,Changsha 410013,China

Department of Pediatric Orthopedics,Hunan Children's Hospital,University of South China,Changsha 410007,China

Department of Respiratory Medicine,Xiangya Hospital,Central South University,Changsha 410008,China

School of Nursing,Xinjiang Medical University,Urumqi,Xinjiang 830000,China

Department of Rehabilitation,Xiangya Hospital,Central South University,Changsha 410008,China

National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China

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国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Science and Technology Innovation Program of Hunan ProvinceScience and Technology Innovation Program of Hunan ProvinceChina National Postdoctoral Program for Innovative TalentsCentral South University Innovation-Driven Research ProgrammeCentral South University Innovation-Driven Research ProgrammeHunan Province Natural Science Foundation of ChinaHunan Province Natural Science Foundation of ChinaYouth Science Foundation of Xiangya HospitalHunan Provincial Innovation Foundation For PostgraduateHunan Provincial Innovation Foundation For Postgraduate

8212502382072504818718228217250181801395822000392020RC40082022RC1211BX20213832023CXQD0012019CX0142023JJ100942020JJ58832022Q072021ZZTS03422022ZZTS0239

2024

10.1016/j.apsb.2023.12.009

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(3)
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