Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

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外文摘要：Cancer immunotherapy has garnered promise in tumor progression,invasion,and metastasis through establishing durable and memorable immunological activity.However,low response rates,adverse side effects,and high costs compromise the additional benefits for patients treated with current chemical and biological agents.Chinese herbal medicines(CHMs)are a potential treasure trove of nat-ural medicines and are gaining momentum in cancer immunomodulation with multi-component,multi-target,and multi-pathway characteristics.The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms.Additionally,the introduction of nanotech-nology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity,stability,permeability,and targeting characteristics,further enhancing anti-cancer immu-nity.In this review,we summarize the mechanism of active ingredients for cancer immunomodulation,highlight nano-formulated deliveries of active ingredients for cancer immunotherapy,and provide in-sights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

外文关键词：

Chinese herbal medicinesNano-formulationActive ingredientsDrug deliveryCancer immunotherapyInnate immune systemAdaptive immune system

作者：

Qi Shang、Wandong Liu、Faith Leslie、Jiapei Yang、Mingmei Guo、Mingjiao Sun、Guangji Zhang、Qiang Zhang、Feihu Wang

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作者单位：

School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

School of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China

Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province,Hangzhou 310053,China

Department of Chemical and Biomolecular Engineering,Whiting School of Engineering,the Johns Hopkins University,Baltimore,MD 21218,USA

Traditional Chinese Medicine"Preventing Disease"Wisdom Health Project Research Center of Zhejiang,Hangzhou 310053,China

Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

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基金：

国家重点研发计划Key Project at Central Government Level国家自然科学基金Science and Technology Commission of Shanghai Municipal,ChinaMedicine-Engineering joint foundation of Shanghai Jiao Tong University,ChinaMedicine-Engineering joint foundation of Shanghai Jiao Tong University,China

项目编号：

2022YFC3501905206030282104076STCSM22S21902400YG2022QN025YG2022QN050

出版年：

2024

DOI：

10.1016/j.apsb.2023.12.008

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(4)

参考文献量168