首页|Emerging non-antibody-drug conjugates(non-ADCs)therapeutics of toxins for cancer treatment

Emerging non-antibody-drug conjugates(non-ADCs)therapeutics of toxins for cancer treatment

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The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins.In recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their effi-cient killing activity against various cancer cells.Although ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ADCs.Recently,non-ADC delivery strategies for toxins have been extensively investigated.To further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery systems.In addition,toxins and their combination strategies with other therapies were discussed.Finally,the prospect and challenge of toxins in cancer treatment were also summarized.

ToxinsNon-antibody-drug conjugatesDelivery strategiesProdrugsNano drug delivery systemsBiomimetic drug delivery systemsCombination strategiesCancer treatment

Xiaolan Xu、Jiaming Zhang、Tao Wang、Jing Li、Yukang Rong、Yanfang Wang、Chenxia Bai、Qing Yan、Xiaohua Ran、Yingli Wang、Tianhong Zhang、Jin Sun、Qikun Jiang

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Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China

School of Education,University of Nottingham,Nottingham NG7 2RD,UK

Department of Pharmacy,Linyi People's Hospital,Shandong University,Linyi 276000,China

State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100871,China

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National Postdoctoral Foundation of ChinaLiaoning Province Department of Education Project,ChinaState Key Laboratory of Natural and Biomimetic Drugs,China国家自然科学基金Liaoning Province Applied Basic Research Program,China山东省自然科学基金

2023M730375LJKMZ20221365K202215821737662022JH2/101300097ZR2021QH084

2024

10.1016/j.apsb.2023.11.029

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(4)
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