首页|The emerging tumor microbe microenvironment:From delineation to multidisciplinary approach-based interventions

The emerging tumor microbe microenvironment:From delineation to multidisciplinary approach-based interventions

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Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful influence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in low-biomass.The accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional one.Therefore,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying mechanisms.Herein,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,inflammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed biomaterials.We hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

Tumor microbe microenvironmentMicrobiota metabolitesImmunomodulationChemoresistanceMultidisciplinary approachGenetically engineered microbiotaAutophagyOuter membrane vesicles

Yu Fu、Jia Li、Wenyun Cai、Yulan Huang、Xinlong Liu、Zhongyi Ma、Zhongjie Tang、Xufei Bian、Ji Zheng、Jiayun Jiang、Chong Li

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Medical Research Institute,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China

Department of Urology,Urologic Surgery Center,Xinqiao Hospital,Third Military Medical University(Army Medical University),Chongqing 400037,China

Institute of Hepatobiliary Surgery,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China

国家自然科学基金重庆市自然科学基金Chongqing Science Fund for Distinguished Young Scholars,ChinaKey project for clinical innovation of Army Medical University,ChinaInnovative Research Group at Higher Educational Institutions in Chongqing,ChinaDoctoral Through Train Scientific Research Project of Chongqing,China

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2024

10.1016/j.apsb.2023.11.018

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(4)
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