首页|Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and function.The natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or dysfunction.In this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell levels.Our results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer cells.These findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

Rosmarinic acidDiabetic nephropathyscRNA sequencingInjuryOxidative stressInflammationProteomics

Junhui Chen、Qian Zhang、Jinan Guo、Di Gu、Jing Liu、Piao Luo、Yunmeng Bai、Jiayun Chen、Xinzhou Zhang、Sheng Nie、Chunbo Chen、Yulin Feng、Jigang Wang

展开 >

National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,China

Department of Pulmonary and Critical Care Medicine,Shenzhen Institute of Respiratory Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,First Affiliated Hospital of Southern University of Science and Technology,Second Clinical Medical College of Jinan University,Shenzhen 518020,China

School of Traditional Chinese Medicine and School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China

Department of Urology,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People,s Hospital,the First Affiliated Hospital,Southern University of Science and Technology,Shenzhen 518020,China

Department of Urology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510230,China

Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital,the First Affiliated Hospital,Southern University of Science and Technology,Shenzhen 518020,China

Department of Nephrology,Nanfang Hospital,the First Affiliated Hospital of Southern Medical University,Guangzhou 510515,China

Department of Critical Care Medicine,Shenzhen People,s Hospital(the Second Clinical Medical College,Jinan University,the First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518020,China

School of Traditional Chinese Medici

展开 >

&&国家重点研发计划国家重点研发计划Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine,China国家自然科学基金国家自然科学基金Fundamental Research Funds for the Central Public Welfare Research Institutes,ChinaFundamental Research Funds for the Central Public Welfare Research Institutes,ChinaFundamental Research Funds for the Central Public Welfare Research Institutes,ChinaFundamental Research Funds for the Central Public Welfare Research Institutes,ChinaFundamental Research Funds for the Central Public Welfare Research Institutes,ChinaFundamental Research Funds for the Central Public Welfare Research Institutes,ChinaShenzhen Science and Technology Innovation Commission,ChinaShenzhen Science and Technology Innovation Commission,ChinaShenzhen Medical Research Fund,ChinaDistinguished Expert Project of Sichuan Province Tianfu Scholar,ChinaCACMS Innovation Fund,ChinaCACMS Innovation Fund,ChinaCACMS Innovation Fund,ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Daodi HerbsScientific and technological innovation project of China Academy of Chinese Medical Sciences,ChinaScientific and technological innovation project of China Academy of Chinese Medical Sciences,China

2020YFE02051002020YFA09080002022YFC2303600ZYYCXTD-C-2020028207409881841001ZZ16-ND-10-23ZZ15-ND-10ZZ14-ND-010ZZ14-FL-002ZZ14-YQ-050ZZ14-YQ-051JCYJ20210324115800001JCYJ20210324114014039B2302051CW202002CI2023E002CI2021A05101CI2021A05104CI2023D003CI2021B014

2024

10.1016/j.apsb.2024.01.003

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(4)
  • 70