首页|A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood-brain barrier selective-opening
A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood-brain barrier selective-opening
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on selective opening of the BBB.This strategy allows some simple bare nanoparticles to enter the brain when mixed with special opening material;however,the BBB still maintains the ability to completely block molecules from passing through.Based on the screening of BBB opening and matrix delivery mate-rials,we determined that phospholipase A2-catalyzed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine li-posomes can efficiently carry drugs into the brain immediately.At an effective dose,this delivery system is safe,especially with its effect on the BBB being reversible.This mix & act delivery system has a simple structure and rapid preparation,making it a strong potential candidate for drug delivery across the BBB.
NETL
NSTL
万方数据
