首页|Ginsenoside modified lipid-coated perfluorocarbon nanodroplets:A novel approach to reduce complement protein adsorption and prolong in vivo circulation

Ginsenoside modified lipid-coated perfluorocarbon nanodroplets:A novel approach to reduce complement protein adsorption and prolong in vivo circulation

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Lipid-coated perfluorocarbon nanodroplets(lp-NDs)hold great promise in bio-medicine as vehicles for drug delivery,molecular imaging and vaccine agents.However,their clinical utility is restricted by limited targeted accumulation,attributed to the innate immune system(ⅡS),which acts as the initial defense mechanism in humans.This study aimed to optimize lp-ND formulations to mini-mize non-specific clearance by the ⅡS.Ginsenosides(Gs),the principal components of Panax ginseng,possessing complement inhibition ability,structural similarity to cholesterol,and comparable fat solubi-lity to phospholipids,were used as promising candidate ⅡS inhibitors.Two different types of ginsenoside-based lp-NDs(Gs lp-NDs)were created,and their efficacy in reducing ⅡS recognition was examined.The Gs lp-NDs were observed to inhibit the adsorption of C3 in the protein corona(PC)and the generation of SC5b-9.Adding Gs to lp-NDs reduced complement adsorption and phagocytosis,resulting in a longer blood circulation time in vivo compared to lp-NDs that did not contain Gs.These results suggest that Gs can act as anti-complement and anti-phagocytosis adjuvants,potentially reducing non-specific clear-ance by the ⅡS and improving lifespan.

Lipid-coated perfluorocarbon nanodropletsProtein coronaComplement C3PhagocytosisGinsenoside lipid-coated perfluorocarbon nanodropletsInnate immune systemComplement systemMononuclear phagocytic system

Jie Zhou、Binyang Gao、Huan Zhang、Rui Yang、Jianbo Huang、Xin Li、Yi Zhong、Yan Wang、Xiaoxia Zhu、Yan Luo、Feng Yan

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Ultrasound Department of West China Hospital,Sichuan University,Chengdu 610041,China

Laboratory of Ultrasound Imaging of West China Hospital,Sichuan University,Chengdu 610041,China

West China Washington Mitochondria and Metabolism Research Center West China Hospital,Sichuan University,Chengdu 610041,China

Research Core Facilities of West China Hospital,Sichuan University,Chengdu 610041,China

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国家自然科学基金青年基金国家自然科学基金国家自然科学基金Medical Research Project of Chengdu Municipal Health Commission,ChinaMedical Research Project of Chengdu Municipal Health Commission,China

82302199823719778207194020210172022338

2024

10.1016/j.apsb.2023.11.016

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(4)
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