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Bile acids and coronavirus disease 2019

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The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has been significantly alleviated.However,long-term health effects and prevention strategy remain unresolved.Thus,it is essential to explore the pathophysiological mechanisms and intervention for SARS-CoV-2 infection.Emerging research indicates a link between COVID-19 and bile acids,traditionally known for facilitating dietary fat absorption.The bile acid urso deoxycholic acid potentially protects against SARS-CoV-2 infection by inhibiting the farnesoid X recep-tor,a bile acid nuclear receptor.The activation of G-protein-coupled bile acid receptor,another mem brane receptor for bile acids,has also been found to regulate the expression of angiotensin-converting enzyme 2,the receptor through which the virus enters human cells.Here,we review the latest basic and clinical evidence linking bile acids to SARS-CoV-2,and reveal their complicated pathophysiological mechanisms.

Bile acidsCOVID-19Famesoid X receptorG-protein-coupled bile acid receptorSARS-CoV-2Angiotensin-converting enzyme 2Ursodeoxycholic acidChenodeoxycholic acid

Xiaoru Huang、Xuening Liu、Zijian Li

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Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China

Department of Pharmaceutical Management and Clinical Pharmacy,College of Pharmacy,Peking University,Beijing 100191,China

Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Beijing Key Laboratory of Cardiovascular Receptors Research,Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking

国家自然科学基金国家自然科学基金国家自然科学基金国家重点研发计划Beijing Municipal Natural Science Foundation,ChinaMedical research management/basic and clinical research unit of metabolic cardiovascular diseases,Chinese Academy of Medical Sci

U21A2033681820108031919393012022YFC360240072222182021RU003

2024

10.1016/j.apsb.2024.02.011

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(5)
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