首页|Stepping forward:T-cell redirecting bispecific antibodies in cancer therapy

Stepping forward:T-cell redirecting bispecific antibodies in cancer therapy

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T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These anti-bodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cell-redirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ulti-mate goal of expanding the application of this therapy to include solid tumors.

Bispecific antibody(BsAbs)T-cell redirecting BsAbsTumor-associated antigensToxicityCytokine release syndromeTumor microenvironmentCancer immunotherapyCombination therapy strategies

Xiaojing Qin、Wenjing Ning、Han Liu、Xue Liu、Wenxin Luo、Ningshao Xia

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State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,School of Public Health,Xiamen University,Xiamen 361102,China

National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Innovation Platform for Industry-Education Integration in Vaccine Research,the Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences,Xiamen University

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationPostdoctoral Innovation Talents Support Program,ChinaScience and Technology Planning Project of Fujian Province,ChinaCAMS Innovation Fund for Medical Sciences,China

32070940819914912021M700115BX202201892022L30802019RU022

2024

10.1016/j.apsb.2024.03.027

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(6)
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