首页|Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

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The visualization of drugs in living systems has become key techniques in modem therapeu-tics.Recent advancements in optical imaging technologies and molecular design strategies have revolu-tionized drug visualization.At the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to drugs.Moving beyond sub-cellular imaging,researchers have integrated multiple modes,like optical near-infrared Ⅱ imaging,to study the complex spatiotemporal interactions between drugs and their surroundings.By combining these visualization approaches,researchers gain supplementary information on physiological parameters,meta-bolic activity,and tissue composition,leading to a comprehensive understanding of drug behavior.This review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules used.Additionally,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug visualization.With the integration of advanced imaging technology and molecular design,drug visuali-zation has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

Optical imagingDrug visualizationFluorophore labelingTherapeutics

Ting Sun、Huanxin Zhao、Luyao Hu、Xintian Shao、Zhiyuan Lu、Yuli Wang、Peixue Ling、Yubo Li、Kewu Zeng、Qixin Chen

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School of Pharmaceutical Sciences,National Key Laboratory of Advanced Drug Delivery System,Medical Science and Technology Innovation Center,Shandong First Medical University & Shandong Academy of Medical Sciences,Jinan 250062,China

Institute of Biochemical and Biotechnological Drugs,School of Pharmaceutical Sciences,Cheeloo College of Medicine,Shandong University,Jinan 250012,China

School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

School of Life Sciences,Science and Technology Innovation Center,Shandong First Medical University &Shandong Academy of Medical Sciences,Jinan 250062,China

Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute,Tianjin 300457,China

Key Laboratory of Systems Bioengineering(Ministry of Education),School of Chemistry Engineering and Technology,Tianjin University,Tianjin 300072,China

Key Laboratory of Biopharmaceuticals,Postdoctoral Scientific Research Workstation,Shandong Academy of Pharmaceutical Science,Jinan 250098,China

State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

Departments of Diagnostic Radiology,Surgery,Chemical and Biomolecular Engineering,and Biomedical Engineering,Yong Loo Lin School of Medicine and College of Design and Engineering,National University of Singapore,Singapore 119074,Singapore

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Shandong Province Key R&D Program Major Technological Innovation Project,ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaYoung Elite Scientists Sponsorship Program by CACM,Chinakey Program of Natural Science Foundation of Shandong Province,ChinaNatural Science Foundation of Shandong Province,ChinaNatural Science Foundation of Shandong Province,ChinaNatural Science Foundation of Shandong Province,ChinaNatural Science Foundation of Shandong Province,ChinaInnovation Team of Shandong Higher School Youth Innovation Technology Program,ChinaInnovation Team of Shandong Higher School Youth Innovation Technology Program,ChinaTaishan Scholars Project in Shandong Province,ChinaTaishan Scholars Project in Shandong Province,ChinaTaishan Scholars Project in Shandong Province,ChinaShandong Science Fund for Excellent Young Scholars,ChinaJinan New 20 Policies for Higher Education Funding,ChinaNatural Science Foundation of Shandong Province(Joint Fundation for Innovation and Development),ChinaYouth Qihuang Scholars Support Program of the State Administration of Traditional Chinese MedicineTianjin Graduate Research Innovation Project General Project,ChinaTUTCM Graduate Research Innovation Project(General Project)Shandong Province Traditional Chinese Medicine Science and Technology Project,China

2021CXGC01050122107059220070603230095782141209CACM-2023-QNRC1-02ZR2023ZD25ZR2021QH057ZR2022QH304ZR2020QB166ZR2023QH4272021KJ0352022KJ197TSPD20181218TSTP20230633TSQN202211221ZR2022YQ66202228048ZR2022LZY0212022BKY180M-2023208

2024

10.1016/j.apsb.2024.01.018

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(6)
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