首页|Interferon-induced MXB protein restricts vimentin-dependent viral infection

Interferon-induced MXB protein restricts vimentin-dependent viral infection

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Type Ⅰ interferon(IFN)inhibits a wide spectrum of viruses through stimulating the expres-sion of antiviral proteins.As an IFN-induced protein,myxovirus resistance B(MXB)protein was reported to inhibit multiple highly pathogenic human viruses.It remains to be determined whether MXB employs a common mechanism to restrict different viruses.Here,we find that IFN alters the subcellular localization of hundreds of host proteins,and this IFN effect is partially lost upon MXB deple-tion.The results of our mechanistic study reveal that MXB recognizes vimentin(VIM)and recruits pro-tein kinase B(AKT)to phosphorylate VIM at amino acid S38,which leads to reorganization of the VIM network and impairment of intracellular trafficking of virus protein complexes,hence causing a restric-tion of virus infection.These results highlight a new function of MXB in modulating VIM-mediated traf-ficking,which may lead towards a novel broad-spectrum antiviral strategy to control a large group of viruses that depend on VIM for successful replication.

MXBVimentinBroad antiviral strategyCytoskeleton networkAKT

Dongrong Yi、Ni An、Quanjie Li、Qian Liu、Huihan Shao、Rui Zhou、Jing Wang、Yongxin Zhang、Ling Ma、Fei Guo、Xiaoyu Li、Zhenlong Liu、Shan Cen

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Institute of Medicinal Biotechnology,Chinese Academy of Medical Science,Beijing 100050,China

Institute of Pathogen Biology,Chinese Academy of Medical Science,Beijing 100730,China

Lady Davis Institute for Medical Research,Jewish General Hospital,Montreal,Quebec H3T 1E2,Canada

authors appreciate the National Microbial Resource CenterCAMS Collection Center of Pathogenic Microorganisms(CAMS-CCPM-A)Beijing Natural Science FoundationNational Natural Science Foundation of ChinaCAMS Innovation Fund for Medical SciencesCAMS Innovation Fund for Medical SciencesCAMS Innovation Fund for Medical Sciences

NMRC-2020-37242097819020752021-I2M-1-0382021-I2M-1-0302021-I2M-1-043

2024

10.1016/j.apsb.2024.03.029

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(6)
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