Single-domain antibodies as therapeutics for solid tumor treatment

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外文摘要：Single-domain antibodies(sdAbs),initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs,have emerged as a promising alternative to conventional therapeutic antibodies.These sdAbs have many superior physicochemical and pharmacological properties,including small size,good solubility and thermostability,easier accessible epitopes,and strong tissue penetration.However,the inherent challenges associated with the animal origin of sdAbs limit their clinical use.In recent years,various innovative humanization technologies,including complementarity-determining re-gion(CDR)grafting or complete engineering of fully human sdAbs,have been developed to mitigate po-tential immunogenicity issues and enhance their compatibility.This review provides a comprehensive exploration of sdAbs,emphasizing their distinctive features and the progress in humanization methodol-ogies.In addition,we provide an overview of the recent progress in developing drugs and therapeutic strategies based on sdAbs and their potential in solid tumor treatment,such as sdAb-drug conjugates,multispecific sdAbs,sdAb-based delivery systems,and sdAb-based cell therapy.

外文关键词：

Single-domain antibodyNanobodyHumanizationFully human single-domain antibodySolid tumor

作者：

Mingkai Wang、Tianlei Ying、Yanling Wu

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作者单位：

MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology,School of Basic Medical Sciences,Department of Pulmonary and Critical Care Medicine,Department of Liver Surgery and Transplantation,Zhongshan Hospital,Fudan University,Shanghai 200032,China

Shanghai Engineering Research Center for Synthetic Immunology,Shanghai 200032,China

基金：

National Key R&D Program of ChinaNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai Municipality,ChinaShanghai Municipal Health Commission,China

项目编号：

2019YFA09044003227098423XD1400800GWVI-11.2-YQ46

出版年：

2024

DOI：

10.1016/j.apsb.2024.03.016

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(7)