Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy

扫码查看

原文链接

NETL
NSTL
万方数据

外文摘要：Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging population.The relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of malignancies.Herein,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclin-ical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

外文关键词：

ComplicationsComorbiditiesChemotherapyPreclinical cancer modelsDrug designDrug delivery

作者：

Xiaoman Mao、Shuang Wu、Dandan Huang、Chong Li

展开 >

作者单位：

College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China

Medical Research Institute,Southwest University,Chongqing 400715,China

School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China

基金：

National Natural Science Foundation of ChinaChongqing Science Fund for Distinguished Young Scholars,ChinaFundamental Research Funds for the Central Universities,Chinaproject for Chongqing University Innovation Research Group,Chongqing Education Committee,China

项目编号：

82373808CSTB2023NSCQ-JQX0021SWURC2020001CXQT200006

出版年：

2024

DOI：

10.1016/j.apsb.2024.03.006

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(7)