Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2

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原文链接

NETL
NSTL
万方数据

外文关键词：

Non-covalent PLpro inhibitorsAntiviral activityStructural-based drug designImidazo[4,5-b]pyridine scaffold

作者：

Miao Zheng、Bo Feng、Yumin Zhang、Xin Liu、Na Zhao、Hui Liu、Zichao Xu、Xinheng He、Zhiyan Qu、Shizhao Chen、Zhidong Jiang、Xi Cheng、Hong Liu、Yi Zang、Linxiang Zhao、Jie Zheng、Leike Zhang、Jia Li、Yu Zhou

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作者单位：

Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China

Shanghai Institute of Materia Medico,Chinese Academy of Sciences,Shanghai 201203,and University of Chinese Academy of Sciences,Beijing 100049,China

School of Life Sciences and Biopharmaceuticals,Shenyang Pharmaceutical University,Shenyang 110016,China

State Key Laboratory of Chemical Biology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,and University of Chinese Academy of Sciences,Beijing 100049,China

State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China

Lingang Laboratory,Shanghai 200031,China

Hubei Jiangxia Laboratory,Wuhan 430200,China

School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaStrategic Priority Research Program of Chinese Academy of SciencesStrategic Priority Research Program of Chinese Academy of SciencesShanghai Institute of Materia Medica of Chinese Academy of Sciences

项目编号：

8215121982130105SIMM010109SIMM010111SIMM0120231003

出版年：

2024

DOI：

10.1016/j.apsb.2024.04.011

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(7)